Using 75 g OGTT in Prediction for Macrosomia in Gestational Diabetes Mellitus

Gestational Diabetes mellitus (GDM) is defined as carbohydrate intolerance with different degrees of severity which occurs or is recognized for the first time during pregnancy. Fetal birth weight above the 90th percentile for gestational week and newborns weight equal or higher than 4000 g is defined as macrosomia [1]. About 15-45% of babies born from mothers with GDM can have macrosomia, which is 3-fold higher in comparison to normoglycemic controls (12%). Macrosomic infants from mothers with GDM are related to risk of developing overweight, obesity in adulthood, and type 2 diabetes mellitus and cardiovascular diseases later in life. Several studies showed that epigenetic alterations of different genes of the fetuses of a GDM mother in utero could result in transgenerational transmission of GDM and type 2 diabetes mellitus [1]. Thus, hyperglycemia begets hyperglycemia.